2
A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.
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Acyclovir is a synthetic purine nucleoside analogue with
in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2),
and varicella-zoster virus (VZV).
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in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2),
and varicella-zoster virus (VZV).
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Acute Treatment of Herpes Zoster: 800 mg every 4 hours orally, 5 times daily for 7 to
10 days.
Genital Herpes: Treatment of Initial Genital Herpes: 200 mg every 4 hours, 5 times daily
for 10 days.
- Chronic Suppressive Therapy for Recurrent Disease: 400 mg 2 times daily for up to
12 months, followed by re-evaluation. Alternative regimens have included doses ranging from
200 mg 3 times daily to 200 mg 5 times daily.
-The frequency and severity of episodes of untreated genital herpes may change over time.
After 1 year of therapy, the frequency and severity of the patient’s genital herpes infection
should be re-evaluated to assess the need for continuation of therapy with ZOVIRAX.
-Intermittent Therapy: 200 mg every 4 hours, 5 times daily for 5 days. Therapy should be
initiated at the earliest sign or symptom (prodrome) of recurrence.
Treatment of Chickenpox: Children (2 years of age and older): 20 mg/kg per dose
orally 4 times daily (80 mg/kg/day) for 5 days. Children over 40 kg should receive the adult dose
for chickenpox.
Adults and Children over 40 kg: 800 mg 4 times daily for 5 days.
Intravenous ZOVIRAX is indicated for the treatment of varicella-zoster infections in
immunocompromised patients.
When therapy is indicated, it should be initiated at the earliest sign or symptom of
chickenpox. There is no information about the efficacy of therapy initiated more than 24 hours
after onset of signs and symptoms.
Patients With Acute renal-impairment or Chronic Renal-Impairment: In patients with renal impairment,
the dose of ZOVIRAX Capsules, Tablets, or Suspension should be modified as shown.
Hemodialysis: For patients who require hemodialysis, the mean plasma half-life of acyclovir
during hemodialysis is approximately 5 hours. This results in a 60% decrease in plasma
concentrations following a 6-hour dialysis period. Therefore, the patient’s dosing schedule
should be adjusted so that an additional dose is administered after each dialysis.
Peritoneal Dialysis: No supplemental dose appears to be necessary after adjustment of the
dosing interval.
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10 days.
Genital Herpes: Treatment of Initial Genital Herpes: 200 mg every 4 hours, 5 times daily
for 10 days.
- Chronic Suppressive Therapy for Recurrent Disease: 400 mg 2 times daily for up to
12 months, followed by re-evaluation. Alternative regimens have included doses ranging from
200 mg 3 times daily to 200 mg 5 times daily.
-The frequency and severity of episodes of untreated genital herpes may change over time.
After 1 year of therapy, the frequency and severity of the patient’s genital herpes infection
should be re-evaluated to assess the need for continuation of therapy with ZOVIRAX.
-Intermittent Therapy: 200 mg every 4 hours, 5 times daily for 5 days. Therapy should be
initiated at the earliest sign or symptom (prodrome) of recurrence.
Treatment of Chickenpox: Children (2 years of age and older): 20 mg/kg per dose
orally 4 times daily (80 mg/kg/day) for 5 days. Children over 40 kg should receive the adult dose
for chickenpox.
Adults and Children over 40 kg: 800 mg 4 times daily for 5 days.
Intravenous ZOVIRAX is indicated for the treatment of varicella-zoster infections in
immunocompromised patients.
When therapy is indicated, it should be initiated at the earliest sign or symptom of
chickenpox. There is no information about the efficacy of therapy initiated more than 24 hours
after onset of signs and symptoms.
Patients With Acute renal-impairment or Chronic Renal-Impairment: In patients with renal impairment,
the dose of ZOVIRAX Capsules, Tablets, or Suspension should be modified as shown.
Hemodialysis: For patients who require hemodialysis, the mean plasma half-life of acyclovir
during hemodialysis is approximately 5 hours. This results in a 60% decrease in plasma
concentrations following a 6-hour dialysis period. Therefore, the patient’s dosing schedule
should be adjusted so that an additional dose is administered after each dialysis.
Peritoneal Dialysis: No supplemental dose appears to be necessary after adjustment of the
dosing interval.
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Treatment of Chickenpox: Children (2 years of age and older): 20 mg/kg per dose
orally 4 times daily (80 mg/kg/day) for 5 days. Children over 40 kg should receive the adult dose
for chickenpox.
orally 4 times daily (80 mg/kg/day) for 5 days. Children over 40 kg should receive the adult dose
for chickenpox.
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Acyclovir is renally excreted and requires dose adjusting in patients with renal impairment. See the product information. us.gsk.com/products/asset...
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