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Excellent overview refl.in/mp

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If a prolonged APTT is present in the abscence of heparin, a mixing study is indicated

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If an optical density method is used to monitor clot formation, falsely normal APTTs may occur if the patient’s plasma is turbid (e.g. hyperbilirubinaemia, hyperlipidaemia). refl.in/mp

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If the APTT is prolonged in the absence of heparin, mixing studies can be performed to assess the presence of lupus anticoagulants or deficiencies of clotting factors

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