Cyclizine
Drug
 
Aliases:
Marezine

Topic aliases are alternate phrasings for a particular topic.


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A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
www.nlm.nih.gov/cgi/mesh/...

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This drug is effective for preventing postoperative nausea and vomiting, and is comparable to other antiemetics such as ondansetron, granisetron and droperidol. Cyclizine is not recommended for children and there have been no studies in older people.
www.australianprescriber.... Aust Prescr 2012;35:208-10

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Although evidence for efficacy in preventing PONV only in certain patient groups. See article.
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Because of its anticholinergic effects, cyclizine may precipitate urinary retention and incipient glaucoma. Monitoring is recommended in patients with glaucoma, obstructive disease of the intestine, liver disease, epilepsy and prostatic hypertrophy. As cyclizine may cause thickening of bronchial secretions, it should be used with caution in patients with asthma or chronic obstructive pulmonary disease. This drug may increase the adverse effects of other anticholinergic drugs.
www.australianprescriber.... Aust Prescr 2012;35:208-10

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Cyclizine’s antiemetic effect lasts for approximately four hours. The elimination half-life is around 14 hours following a single 25mg intravenous dose. Cyclizine can be given up to three times a day but treatment should not continue beyond 48 hours.
www.australianprescriber.... Aust Prescr 2012;35:208-10

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Australian prescriber review of Cyclizine for post operative-nausea-and-vomiting.
www.australianprescriber....

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