In the treatment of suspected malignant hyperthermia: 2.5mg/kg IV every 5mins to effect. This paper suggests maximum dose 20mg/kg. Continue at an infusion rate of 10mg/kg/day for at least 24hrs. refl.in/d0
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Feb 17, 2013
Warming the diluent to 40 degrees celcius reduced time to dissolve from >50 seconds to 4 seconds for the newer Dantrolene preparation by US WorldMeds. Note that according to this author the manufacturer does not recommend this. refl.in/mr and refl.in/ms
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Dec 22, 2011
Packaged in 20mg bottles with NaOH for a pH of 9 to 10 (to help it dissolve) plus mannitol (converts the hypotonic solution to isotonic).
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Aug 10, 2011
Dantrolene is a direct-acting skeletal muscle relaxant blocking calcium release from intracellular storage in the sarcoplasmic reticulum. Muscle contraction is decreased without an effect on the action potential patterns of the NMJ refl.in/d0
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Aug 10, 2011
Full product information (JHP pharmaceuticals) refl.in/f/Dantrolene.pdf
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Dec 22, 2011