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Presentation is characterised by the onset of predominantly bilious vomiting (unless the atresia is proximal to the ampulla of vater) in the hours following birth.
Partial obstructions may present later in childhood.

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Electrolyte studies and venous blood-gas in patients that have been vomiting will often reveal a hypochloraemic metabolic-alkalosis

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"Approximately half of all infants with duodenal atresia or stenosis will also have a congenital anomaly of another organ system [4]. Duodenal atresia is associated with Downs syndrome (30%), annular pancreas (23%), congenital heart-disease (22%), malrotation (20%), oesophageal atresia (8%), others (20%)" www.casesjournal.com/cont...

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