Enigma I Trial
Trial/Study
 
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The ENIGMA I multi-center trial (Evaluation of Nitrous Oxide in the Gas Mixture for Anesthesia) showed that inclusion of nitrous oxide in the gas mixture during general anaesthesia led to no differences in the patient's length of stay (as a combined endpoint of complications).

Anesthesiology 2007

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N2O 70% for cases >2hrs would increase length of stay.

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Patients randomised in two groups.

Volatile agent plus either 80/20:Oxygen/Nitrogen or 30/70:Oxygen/Nitrous oxide for surgery >2hrs in duration.

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The primary endpoint of length of stay was not statistically different between the groups.

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Wound infection (OR 0.72)
Severe PONV (OR 0.4)
Fever (OR 0.74)
Pneumonia 3% vs 1.5%(OR 0.5)

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Flawed because two variables were modified. Both the [O2] concentration and [N2O] concentration were modified meaning outcome differences could be attributed to either variable.

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