Drug
 
Aliases:
Clexane
Lovenox
Xaparin

Topic aliases are alternate phrasings for a particular topic.


Low-molecular-weight fragment of heparin, having a 4-enopyranosuronate sodium structure at the non-reducing end of the chain. It is prepared by depolymerization of the benzylic ester of porcine mucosal heparin. Therapeutically, it is used as an antithrombotic agent. (From Merck Index, 11th ed) www.nlm.nih.gov/cgi/mesh/...

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Adequacy of anticoagulation is determined by measuring Anti Xa-activity.
Normal anti-Xa levels are not to be used to determine whether it is safe to perform surgical or anaesthetic procedures where bleeding is a concern. #ref

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Low measured anti-Xa activity in the context of recent LMWH admimistration does not necessarily indicate a coagulation profile that is considered safe for neuraxial blockade. refl.in/ie

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LMWH has a greater inhibitory effect against Xa than thrombin compared to unfractionated heparin. refl.in/ie

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