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Randomised control trial undertaken in East African children presenting with febrile illness and impaired perfusion to receive boluses of 20 to 40 ml of 5% albumin solution (albumin-bolus group) or 0.9% saline solution (saline-bolus group) per kilogram of body weight or no bolus (control group) at the time of admission to a hospital in Uganda, Kenya, or Tanzania.
Fluid boluses significantly increased 48-hour mortality in critically ill children with impaired perfusion in these resource-limited settings in Africa.
Fluid boluses significantly increased 48-hour mortality in critically ill children with impaired perfusion in these resource-limited settings in Africa.
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Mar 11, 2013
#smacc2013 The nature of the underlying disease in this study population in East Africa included malaria, severe anaemia, and HIV.
Take care when extrapolating the results of this study to a population in which the underlying cause of fever and poor perfusion are likely to be different.
Take care when extrapolating the results of this study to a population in which the underlying cause of fever and poor perfusion are likely to be different.
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Mar 14, 2013
Mortality after Fluid Bolus in African Children with Severe Infection
www.nejm.org/doi/full/10....
June 30, 2011
N Engl J Med 2011; 364:2483-2495
www.nejm.org/doi/full/10....
June 30, 2011
N Engl J Med 2011; 364:2483-2495
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Mar 11, 2013