Drug
Aliases:
Topic aliases are alternate phrasings for a particular topic.
Apocard
Flecadura
Tambocor
Flecatab
Flecanide
1
Flecainide belongs generally to the membrane stabilising (Class 1) group of antiarrhythmic agents, however, it has its own characteristic electrophysiological effects. Its predominant effect on the transmembrane action potential in single cell preparations from canine Purkinje fibres is to decrease the rate of rise (V max, Phase 0) of the action potential without greatly affecting duration.
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See PI below.
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Nov 29, 2012
IV dose is 2 mg/kg in D5W (precipitates with chloride) over not less than 10 minutes in a monitored hospital environment only.
In view of the serious nature of many of the conditions being treated, the intravenous form of flecainide should be used in hospitals where facilities exist for cardiac monitoring or defibrillation should the need arise. This form should only be used when an immediate effect is clinically desirable.
TAMBOCOR can be given in an emergency or for rapid effect by a slow injection of 2 mg/kg over not less than ten minutes.
If preferred the dose may be diluted with 5% glucose and given as a mini-infusion.
IMPORTANT: Glucose Intravenous Infusion 5% w/v is the only recommended diluent for TAMBOCOR injection. Alkaline solutions or solutions containing chloride should not be used as a diluent as precipitation may occur.
See PI
In view of the serious nature of many of the conditions being treated, the intravenous form of flecainide should be used in hospitals where facilities exist for cardiac monitoring or defibrillation should the need arise. This form should only be used when an immediate effect is clinically desirable.
TAMBOCOR can be given in an emergency or for rapid effect by a slow injection of 2 mg/kg over not less than ten minutes.
If preferred the dose may be diluted with 5% glucose and given as a mini-infusion.
IMPORTANT: Glucose Intravenous Infusion 5% w/v is the only recommended diluent for TAMBOCOR injection. Alkaline solutions or solutions containing chloride should not be used as a diluent as precipitation may occur.
See PI
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Nov 20, 2012
No significant anticholinergic or α or ß antiadrenergic effects have been found in animal studies
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