Aliases:
GTN
Nitroglycerin

Topic aliases are alternate phrasings for a particular topic.


-- Easy bolus dose dilution --

50mg diluted up to 1L Normal Saline results in a 50mcg/mL solution.

Draw 20ml of this up and administer in 0.5-1ml boluses.

Remember to discard the remainder of the 1L bag to ensure it is not accidentally utilised for volume.

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Infusion:

30mg GTN in 50ml Normal Saline gives 600mcg/ml. 1ml/hr is therefore 10mcg/min.

Usual rate is 5-200 microgram/min (0.5-20ml/hr)

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Nebulised as pulmonary vasodilator in pulmonary embolus.

“ Using the concentration of nitroglycerin available in my unit (400 mcg/ml), this would be equivalent to nebulizing 12 ml of nitroglycerin over 15 minutes. So 12 ml of nitroglycerin could simply be nebulized, without any dilution or manipulation. The duration of action is only ~20-30 minutes, ”

emcrit.org/pulmcrit/ntg/

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Setting up dilution for bolus. Take 1ml of 600mcg/ml solution (30mg GTN in 50ml Normal saline) and dilute this up to 12ml in Normal Saline to give a 50mcg/ml GTN solution.

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IV: Initially 0.5 microgram/kg/min increasing gradually to usual dose of 1-5 microgram/kg/min.
Higher doses up to 20 microgram/kg/min have at times been used.

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For an infusion use non-PVC giving set, as GTN is absorbed onto PVC.

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If being administered as an infusion monitor blood pressure continuously.

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Non selective vasodilator so beware of systemic hypotension.

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