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"...prevention of febrile nonhemolytic transfusion reactions, reduction of platelet alloimmunization, and prevention of CMV transmission "
m.anesthesia-analgesia.or...
m.anesthesia-analgesia.or...
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Dec 12, 2012
"Relatively few adverse effects have been reported in association with leukocyte-reduced blood components. A potential side effect involves hypotension. Negatively charged surfaces of leukocyte reduction filters may cause contact activation with release of bradykinin-like vasoactive substances. However, bradykinin is likely not the only factor involved because the concentrations of bradykinin measured in vivo do not reach those expected to cause hypotension. Profound hypotension has been reported in patients taking angiotension-converting-enzyme (ACE) inhibitors and receiving pretransfusion leukocyte-reduced blood products—platelets in particular. Presumably, ACE inhibitors decrease bradykinin degradation thereby prolonging its intravascular half-life. Hypotension also may occur with positively charged leukocyte filters and in patients not taking ACE inhibitors. The United States Food and Drug Administration recently issued an alert highlighting the association between hypotension and leukocyte reduction filters."
m.anesthesia-analgesia.or...
Anesth Analg 2000;90:1315–23
m.anesthesia-analgesia.or...
Anesth Analg 2000;90:1315–23
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Dec 12, 2012
"Watch for a precipitous drop in blood pressure. The primary clinical manifestation of the reaction is the sudden onset of a severe hypotensive episode within one hour of transfusing blood or blood components through a bedside leukocyte reduction filter. The hypotension may be associated with respiratory distress, facial flushing, abdominal pain and nausea, and loss of consciousness."
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Dec 12, 2012