Aliases:
MgSO4
mgs04

Topic aliases are alternate phrasings for a particular topic.


Different hospitals have unique dilutions for the 24/24 MgSO4 infusions. Ensure you use the concentration that ward staff are familiar with to avoid incorrect dosing.

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In severe preeclampsia, an initial loading dose of 4g (8 mL of the 50% solution made up to a safe 20% concentration for IV injection by diluting up to a minimum total volume of 17.5ml) should be given. Administer over 20 minutes if severe preeclampsia, 2-3 minutes if eclampic seizure. refl.in/f/mgso4.pdf refl.in/if

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Intravenous doses should be diluted to a concentration of magnesium 20% or less. For intravenous dosing, each 5 mL ampoule of DBL Magnesium Sulfate Concentrated 50% Injection should be diluted by adding at least 7.5 mL of a compatible solution. refl.in/f/mgso4.pdf

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Monitoring serum magnesium levels and the patient’s clinical status is essential to avoid the consequences of overdosage. Clinical indications of a safe dosage regimen include the presence of the patellar reflex (knee jerk) and absence of respiratory depression. Serum magnesium levels usually sufficient to control convulsions range from 3 to 6 mg/100 mL (2.5 to 5.0 mEq/L). The strength of the deep tendon reflexes begins to diminish when magnesium levels exceed 4 mEq/L. Reflexes may be absent at 10 mEq/L, where respiratory paralysis is a potential hazard. refl.in/f/mgso4.pdf

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Intramuscular injection of 50% MgSO4 solution is appropriate for adults, but 20% should be used in children. refl.in/f/mgso4.pdf

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Magnesium infusion in the management of asthma. Use 50% Mg Sulphate - 0.1ml/kg (50mg/kg) over 20 mins, then 0.06ml/kg/hr (30mg/kg/hour) by infusion.
Aim to keep serum Mg between 1.5 and 2.5mmol/L.
www.rch.org.au/clinicalgu...

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Paediatric bolus dose 0.1-0.2mmol/kg via slow IVI

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To treat hypomagnesemia with MgSO4 50% (2mmol/mL) IV

0.2ml/kg IM or slow IV, then 0.16ml/m2/hr.

refl.in/drugdoses

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An injectable calcium salt should be immediately available to counteract the potential hazards of magnesium intoxication in eclampsia. refl.in/f/mgso4.pdf #improve

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Full product information for 50% Magnesium Sulfate intravenous solution. refl.in/f/mgso4.pdf

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Therapeutic plasma levels are reached within 60 minutes following intramuscular injection, and almost immediately following intravenous injection. refl.in/f/mgso4.pdf

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