.
Morphine
Drug
 
Aliases:
MS Contin
Kapanol
Oramorph
Kadian
MSIR
Avinza

Topic aliases are alternate phrasings for a particular topic.


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Naturally occurring non-specific opiate receptor agonist with low lipid solubility used as systemic and regional analgesic in acute and chronic pain. Side effects of interest include decreased gastric motility, nausea, respiratory depression, sedation, and histamine release during intravenous administration.

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Intrathecal morphine suggested dosing guidelines from:

The Safety And Efficacy of Intrathecal Opioid Analgesia for Acute Postoperative Pain: Seven Years’ Experience with 5969 Surgical Patients at Indiana University Hospital

A & A March 1999 vol. 88 no. 3 599

www.anesthesia-analgesia....

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Intrathecal morphine 1mcg/kg

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Newborns have a slower morphine metabolism, so if using a morphine infusion consider starting at the lower end (eg 10mcg/kg/hr) #ref

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Royal Children's Hospital Melbourne (RCH) opioid infusion chart

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Morphine preparations with sodium metabisulfite as preservative should NOT be administered intrathecally or via an epidural.
www.tga.gov.au/hp/informa...

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Metabolism is primarily hepatic via glucuronidation into morphine-3-glucuronide (M3G) 60% and morphine-6-glucuronide (M6G) 6-10% which are renally excreted.

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M6G is an active metabolite with half the opiate agonist activity of morphine.

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