Drug
Aliases:
Topic aliases are alternate phrasings for a particular topic.
Reversal of muscle relaxant
Prostigmin
Vagostigmin
1
A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
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Aug 12, 2012
Reversal of non-depolarising muscle relaxants
Neostigmine 0.05-0.07mg/kg with Atropine 20 mcg/kg
< 25 kg:
• 1.25 mg Neostigmine, 600 mcg Atropine in 3ml syringe (1/2 Adult)
• Dilute to 3 ml
• Give 0.1 ml/kg
> 25 Kg:
• 2.5 mg Neostigmine, 1200 mcg Atropine in 5 ml syringe
• Dilute to 5 ml
• Give 0.1 ml per kg
Neostigmine 0.05-0.07mg/kg with Atropine 20 mcg/kg
< 25 kg:
• 1.25 mg Neostigmine, 600 mcg Atropine in 3ml syringe (1/2 Adult)
• Dilute to 3 ml
• Give 0.1 ml/kg
> 25 Kg:
• 2.5 mg Neostigmine, 1200 mcg Atropine in 5 ml syringe
• Dilute to 5 ml
• Give 0.1 ml per kg
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Pieter Peach
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Dec 10, 2012
Does not readily cross the blood brain barrier as it is a quaternary amine (unlike the tertiary amine physotigmine) so not as useful in the treatment of the central side effects of anticholinergics (eg confusion). refl.in/fc
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Aug 22, 2011
Inhibits acetylcholinesterase & impairs the hydrolysis of acetylcholine. The increased accumulation of acetylcholine competitively inhibits the non-depolarising muscle relaxants.
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Jul 16, 2011