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Granisetron and tropisetron may reduce the analgesic effect of paracetamol.
"A study in human volunteers showed complete inhibition of the analgesic effect of paracetamol by co-administration of granisetron or tropisetron. The results could not be confirmed with ondansetron; the authors of this study suggest that 5-HT1B and not 5-HT3 receptors are mediating thew analgesic effect of paracetamol.
Overall the clinical relevance of this one reported study are unclear; however, it might well be that use of granisetron and tropisetron, but possibly all 5-HT3 antagonists should be avoided with paracetamol." www.anzca.edu.au/fpm/even...
www.ncbi.nlm.nih.gov/pubm...
"A study in human volunteers showed complete inhibition of the analgesic effect of paracetamol by co-administration of granisetron or tropisetron. The results could not be confirmed with ondansetron; the authors of this study suggest that 5-HT1B and not 5-HT3 receptors are mediating thew analgesic effect of paracetamol.
Overall the clinical relevance of this one reported study are unclear; however, it might well be that use of granisetron and tropisetron, but possibly all 5-HT3 antagonists should be avoided with paracetamol." www.anzca.edu.au/fpm/even...
www.ncbi.nlm.nih.gov/pubm...
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May 14, 2012