Drug
Aliases:
Topic aliases are alternate phrasings for a particular topic.
Demerol
Meperidine
Avoid pethidine in patients taking MAOIs. Two potential interactions are possible. 1. Excitatory form thought due to serotinergic over-activity (serotonin syndrome) characterised by agitation, headache, hyperpyrexia, and seizures. 2. Depressive form thought due to inhibition of hepatic enzymes and accumulation of narcotic, characterised by respiratory depression and hypotension. refl.in/kh
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Tricyclics (eg amitriptyline, doxepin) may enhance the cholinergic, analgesic, and respiratory depression effects of pethidine. Consider avoiding in patients on these medications.
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