1
The POISE (PeriOperative ISchaemic Evaluation) trial published in The Lancet in 2008 suggested high dose peri-operative metoprolol in patients at high risk of atherosclerotic disease undergoing non-cardiac surgery reduces cardiac deaths but increases overall all cause deaths and strokes.
Improve to correct grammar or spelling, but do not significantly alter the substance of the original author's text.
Cancel
Endorsed by
,
more...
Private
only
only
Jan 23, 2013
Perioperative extended release metoprolol in patients with or at high risk of atherosclerotic disease undergoing non-cardiac surgery will reduce risk of major cardiovascular events.
Improve to correct grammar or spelling, but do not significantly alter the substance of the original author's text.
Cancel
Endorsed by
,
more...
Private
only
only
Jan 23, 2013
Patients >45yrs age, non-cardiac surgery expected LOS >24hrs, with any of: CAD; PVD; CVA; admission for CCF in last 3yrs; major vascular surgery (except AVF, vein stripping, CEA), or 3 of: intrathoracic or intraperitoneal surgery; Hx CCF;TIA;diabetes;creatinine >175umol/L;age>70yrs,emergent or urgent surgery.
Randomised to placebo or metoprolol.
100mg ER metoprolol 2-4 hrs before surgery. Another 100mg within 6hrs
postop if BP >100mmHg and HR >80, otherwise at 12hrs. Then 200mg daily 30 days. If NBM IVI (15mg over 60min).
Randomised to placebo or metoprolol.
100mg ER metoprolol 2-4 hrs before surgery. Another 100mg within 6hrs
postop if BP >100mmHg and HR >80, otherwise at 12hrs. Then 200mg daily 30 days. If NBM IVI (15mg over 60min).
Improve to correct grammar or spelling, but do not significantly alter the substance of the original author's text.
Cancel
Endorsed by
,
more...
Private
only
only
Jan 23, 2013
8351 pts
Cardiac death - Placebo 6.9% vs Metoprolol 5.8%
MI - Placebo 5.7% vs Metoprolol 4.2%
CVA - Placebo 0.5% vs Metoprolol 1%
Death - Placebo 2.3% vs Metoprolol 3.1%
Cardiac death - Placebo 6.9% vs Metoprolol 5.8%
MI - Placebo 5.7% vs Metoprolol 4.2%
CVA - Placebo 0.5% vs Metoprolol 1%
Death - Placebo 2.3% vs Metoprolol 3.1%
Improve to correct grammar or spelling, but do not significantly alter the substance of the original author's text.
Cancel
Endorsed by
,
more...
Private
only
only
Jan 23, 2013
Full article anesthesia.mc.duke.edu/wy...
Improve to correct grammar or spelling, but do not significantly alter the substance of the original author's text.
Cancel
Endorsed by
,
more...
Private
only
only
Jan 31, 2013