.
Drug
 
Aliases:
Diprivan
Fresofol

Topic aliases are alternate phrasings for a particular topic.


Rapid onset, short duration alkylphenol intravenous hypnotic agent used primarily for induction, maintanence of anaesthesia, and rapidly reversible procedural and intensive care sedation.

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When using the Marsh model for propofol TIVA, plasma concentration is the appropriate target. refl.in/i6

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When using the Schnider model, it should almost always be used in effect-site targeting mode. refl.in/i6

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Propofol TIVA:
Macfarlan & Kataria model - age 1- 6 yo
15mg/kg/hr 15 min
13 mg/kg/hr for 15 min
11 mg/kg/hr for 45 min
10 mg/kg/hr from 1-2 hr
9 mg/kg/hr from 2-4 hr
Achieves 3 mcg/ml

dx.doi.org/10.1046/j.1460...

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Good 2011 BJA systematic review of research on reducing injection pain. Administration via the antecubital vein RR 0.14. Lignocaine injection with venous occlusion RR 0.29. Lignocaine propofol admixture RR 0.4. Lignocaine pretreatment (no venous occlusion) 0.47. Opioid pretreatment RR 0.49. refl.in/jy

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Reduce pain: IV lidocaine 40 mg, given with a tourniquet 30 to 120 s prior to injection. NNT 1.6 refl.in/59

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Summary of methods to reduce propofol injection pain on www.gasexchange.com/quest...

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Structure

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Mechanism of action: Enhances GABAa activated chloride channels

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