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Purified procoagulant mixture of low molecular weight cationic proteins used in reversal of heparin anticoagulation. Considerations include cautious administration to avoid rapid elevation in pulmonary vascular-resistance, fall in systemic vascular-resistance, and be alert for signs of anaphylaxis.
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Nov 26, 2012
Administer slowly whilst monitoring haemodynamics for evidence of reduced cardiac output.
Protamine elevates pulmonary vascular-resistance (thromboxane release) and reduces SVR (histamine release).
Protamine elevates pulmonary vascular-resistance (thromboxane release) and reduces SVR (histamine release).
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Nov 26, 2012
High incidence of anaphylaxis. Commence with test dose. #ref #improve
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Nov 26, 2012
Protamine is a positively charged base that binds negatively charged acidic heparin to form a salt which is removed by reticuloendothelial system.
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Apr 21, 2012