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Aliases:
PCC
Prothrombin Complex Concentrate

Topic aliases are alternate phrasings for a particular topic.


Freeze dried preparation containing purified human coagulation factors II, IX, X & low levels of factor VII.
Indicated for the treatment & perioperative prophylaxis of bleeding in acquired deficiency of prothrombin complex factors, such as treatment with vitamin K antagonists, & prophylaxis of bleeding in patients with congenital deficiencies of factor IX, II or X when purified specific coagulation factor is not available. www.transfusion.com.au/bl...

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Benefits over FFP:
- No need to thaw product prior to administration.
- INR reversal within 15 minutes.
- The administration of known concentrations of coagulation factors, resulting in a predictable action.
- Reduced need for large volumes of fresh frozen plasma ( FFP ) which can cause circulatory overload.
- No need for ABO blood matching prior to administration.
www.transfusion.com.au/bl...

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Can be given intravenously as a push.

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The dose of PROTHROMBINEX-VF (25-50 IU kg) equates to approximately ½ - 1 vial (500 IU 20mL vial) PROTHROMBINEX-VF per 10 kg patient weight, or 3.5 to 7 vials for a 70kg patient. refl.in/i2 Check INR after 15-30min.

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Vitamin K is then essential for sustaining the reversal achieved by PROTHROMBINEX-VF and FFP due to the limited half-life of the coagulation factors. refl.in/i2

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To reverse wafarin anticoagulation administer 30iu/kg prothrombin X, and reassess in 1hr. If insufficient normalisation, admnister fresh frozen-plasma #ref

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Contraindicated in patients with hypersensitivity to the active substances or to any of the excipients including known allergy to heparin or history of heparin-induced thrombocytopenia (@HIT). Also contraindicated in patients who have evidence of active thrombosis or disseminated intravascular coagulation. refl.in/i2

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FFP is added to provide an additional source of factor VII. The PROTHROMBINEX-VF approved Product Information and the 2004 Warfarin Reversal: Consensus Guidelines developed by the ASTH refl.in/i3 recommend use of both PROTHROMBINEX-VF and FFP in warfarin reversal. PROTHROMBINEX-VF contains factors II, IX and X and low levels of factor VII. refl.in/i2

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Effect of Prothromin Concentrate on warfarin anticoagulation in an acutely bleeding group and a group prior to an interventional procedure.
#ref #spanza2012

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