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Aliases:
Recombinant factor 7a
Novoseven RT
Novo7
Recombinant factor viia
Recombinant vii a
Recombinant 7a
Factor 7a
FVII

Topic aliases are alternate phrasings for a particular topic.


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Recombinant factor VIIa concentrate developed initially for use in haemophilia patients with inhibitors to non-recombinant factor VII.

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Control of bleeding and surgical prophylaxis in patients with:
- inhibitors to coagulation Factors VIII or IX;
- congenital FVII deficiency;
- Glanzmann's Thrombasthenia who have antibodies to GPIIb-IIIa and or HLA, and with past or present refractoriness to platelet transfusions.

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Nov 22, 2012
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For non-surgical bleeding where patient is normothermic, normal acid-base, and where FFP & cryoprecipitate have been administered.

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Mar 09, 2013
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In coagulopathic patients who have undergone massive transfusion, are actively bleeding & meet usual physiological criteria, dose is 100mcg/kg refl.in/81 #improve

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Jun 13, 2011
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In coagulopathic traumatic brain injury requiring urgent craniotomy, a smaller dose of 1mg (~10mcg/kg) is usually sufficient. refl.in/81 #ref #improve

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90mcg/kg IV 2hrly until haemostasis

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Significant risk of thromboembolic complications. Consider risk/benefit ratio. Thomas GOR et al J Trauma 62, 2007. #ref

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Binds to exposed Tissue Factor, directly activates Factor 9 into 9a and Factor 10 into 10a, and thereby initiates conversion of prothrombin to thrombin. Thrombin leads to the activation of platelets and Factors 5 and 8 at the site of injury and conversion of fibrinogen to fibrin which results in the formation of a haemostatic plug.

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