Tramadol
Drug
 
Aliases:
Tramal

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Tramadol is a centrally-acting analgesic indicated for moderate to severe pain. It stimulates opioid receptors, and inhibits noradrenaline and serotonin reuptake. refl.in/8e

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IVI slowly over 2-3 minutes.
For postoperative pain, an initial bolus of 100 mg should be administered. Subsequent doses of 50 mg or 100 mg every four to six hours may be given, up to a total daily dose of 600 mg.
For less severe pain: 50 mg or 100 mg every four to six hours to a maximum of 400 mg per day. refl.in/o3

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2-3mg/kg IV loading dose (max 50-100mg) then 1-2mg/kg (max 50-100mg) every 4-6hrs.

Ref Drug Doses, Frank Shann refl.in/drugdoses

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Co-prescription of tramadol with tricyclic antidepressants, selective serotonin re-uptake inhibitors and antipsychotics can lower the seizure threshold. refl.in/8e

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Ondasetron reduces analgesic effect of tramadol via D2 receptor interaction #ref #improve

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Tramadol is contraindicated in patients who are taking monoamine oxidase inhibitors or who have taken them within the last 14 days due to risk of serotonin syndrome. refl.in/8e

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Tramadol should be avoided in all patients who have epilepsy or are susceptible to seizures unless there are compelling circumstances. refl.in/8e

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Main analgesic effect is via monoamine reuptake inhibition #ref

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Full product information for Tramal refl.in/o3

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