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Tranexamic acid in adults at a dose of 1g within 3hrs of major trauma followed by a further infusion of 1g over 8hrs reduced all-cause mortality and death due to bleeding. CRASH-2 Trial refl.in/lb and followup analysis refl.in/l3

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Oct 15, 2011
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Dose of tranexamic acid utilised in the CARP trial (comparing Tranexamic Acid, Aprotinin, and Aminocaproic acid) was a 30mg/kg loading dose followed by 15mg/kg/hr infusion, and additional 2mg/kg added to the bypass circuit. refl.in/ky

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Aug 29, 2013
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Paediatric dose during Paediatric CPB: 100mg/kg loading followed by 10mg/kg/hr infusion.

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May 09, 2012
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High dose Tranexamic acid is associated with an increased risk of seizure. refl.in/l0 refl.in/l1

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Oct 27, 2012
Dose used in above study on adults used roughly 30mg/kg loading dose & 7.5mg/kg/hr "Tranexamic acid ... 2g was administered at the beginning of CPB and then as a continuous infusion at a rate of 0.5g/h until chest closure; 2g was added to the prime of the CPB equipment"
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Cyklokapron Pfizer full product information refl.in/f/cyklokapronpfiz...

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Jul 24, 2012
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