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Drug
 
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Adults(usual dose)

IV: 500 mg/dose 6 hrly or 1 g/dose 12 hrly
IT,Intraventricular: 20 mg once daily

Pseudomembranous colitis, Staphylococcal enterocolitis
ORAL: 250-500 mg/dose 6 hrly. Not the drug of first-choice for Staphylococcal enterocolitis.
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Neonates

Loading dose of 15 mg/kg then IV:

Preterm: 10 mg/kg/dose 24 hrly
Term: Week 1 of life: 10 mg/kg/dose 12 hrly
Week 2-4 of life: 10 mg/kg/dose 8 hrly
Severe infections: 15 mg/kg/dose

IT,Intraventricular: 5-10 mg once daily

Infants and Children

IV: 10-15 mg/kg/dose 6 hrly
IT,Intraventricular: 5-10 mg once daily (up to 20 mg/day in children)

Pseudomembranous colitis, Staphylococcal enterocolitis
ORAL: 5-10 mg/kg/dose 6 hrly. Round dose to multiple of 125 mg (one capsule). Not the drug of first-choice for Staphylococcal enterocolitis.


Paediatric pharmacokinetic entry ww2.rch.org.au/pharmacopo...

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Avoid rapid IV administration. Do not exceed a rate of 10mg/min. Vancomycin can cause significant reduction in systemic vascular resistance and result in profound hypotension. refl.in/dn

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