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Results of the BART (Blood conservation using Antifibrinolytics in a Randomized Trial) Trial NEJM 2008 suggested that in adult cardiac surgery aprotinin reduces massive haemorhage, but increases overall 30 day mortality.
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Aprotinin would be superior to either tranexamic acid or aminocaproic acid in decreasing massive postoperative bleeding or other clinically important outcomes in cardiac surgery.
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Results --
2331 pts.
Ended early.
Aprotinin reduces tranfusion but increases overall mortality.
Any massive bleeding :
RR 0.79 (vs tranexamic acid) RR 0.79 (vs aminocaproic acid)
30 day mortality
RR 1.55 (vs tranexamic acid)
RR 1.52 (vs aminocaproic acid)
2331 pts.
Ended early.
Aprotinin reduces tranfusion but increases overall mortality.
Any massive bleeding :
RR 0.79 (vs tranexamic acid) RR 0.79 (vs aminocaproic acid)
30 day mortality
RR 1.55 (vs tranexamic acid)
RR 1.52 (vs aminocaproic acid)
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Jan 23, 2013