Patient (condition)
 
Aliases:
Duchenne's muscular dystrophy

Topic aliases are alternate phrasings for a particular topic.


An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)
www.nlm.nih.gov/cgi/mesh/...

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Dilated cardiomyopathy may result from cardiac degeneration due to replacement of myocardium by connective tissue or fat. refl.in/cr

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Reduced vasospasm from smooth muscle involvement in severe disease may result in increased perioperative bleeding.

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At risk of hyperkalemia following the administration of suxamethonium from proliferated extrajunctional neuromuscular junction NMJ receptors

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Lower dose on non-depolarising muscle relaxants NDMR likely required. Monitor with nerve stimulator.

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