Patient (condition)
 
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Characterized by metabolic acidosis, bradycardia, rhabdomyolysis, lipidemia and may lead to cardiac failure.
Described in children at doses of >4mg/kg for >48hrs.
refl.in/fu

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Toxic dose of propofol may be less for children with impaired mitochondrial function. Even a short-term high-dose propofol infusion may result in propofol infusion syndrome, particularly if a child has impaired fatty acid utilization. refl.in/fv

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